Aganocides®

Our proprietary Aganocide compounds work by mimicking our own natural defense against infection. Since our immune system works without ever creating resistance, NovaBay has taken the effective and rapidly acting molecules that function within our own bodies and created stable analogs of these molecules. Our lead Aganocide compound is auriclosene (NVC-422), but we have synthesized several other analogs.
Our Aganocide compounds are:

  • Fast acting
  • Broad in spectrum of activity
  • Effective against multi-drug resistant bacteria
  • Effective against biofilm
  • Have a good safety profile

Fast

Unlike most antibiotics, which can take many hours to kill certain kinds of bacteria, the Aganocide compounds, even at small doses, can kill bacteria in minutes.

Broad spectrum of activity

Our Aganocide compounds have killed, in vitro, all bacteria, viruses, yeasts and fungi against which they have been tested.

Effective against multi-drug resistant bacteria

Our Aganocide compounds were highly effective in in vitro studies against multi-drug resistant bacteria including Methicillin-resistant Staphylococcus aureus (MRSA) and Vancomycin-resistant Enterococcus (VRE).

Effective against biofilm

In data developed at an independent laboratory on our behalf and at our direction, auriclosene was demonstrated to be highly effective against well-established biofilm grown on urinary tract catheters.

High therapeutic index

Auriclosene demonstrates greater in vitro therapeutic index (ratio of toxicity to efficacy) than existing topical antiseptics.